The partnership ranging from BMD and pounds was stronger than between Bmi and you can BMD


The partnership ranging from BMD and pounds was stronger than between Bmi and you can BMD

step three.3. Risk Circumstances

Compared with men with BMI? 25 kg/m 2 , the age-adjusted risk of osteoporosis was over four-fold higher in those with BMI < 25 (odds ratio (OR) 4.4 (1.51, ) in age-adjusted model (Table 3). The association between BMI and osteopenia was similar among overweight/obese and normal weight men, although not statistically significant (Table 3).

Each other Body mass index and you may weight have been correlated with BMD, and you may BMC symptoms while the most effective Pearson’s correlation coefficients were discovered between lbs and you will BMC altogether cool and you can trochanter nations and you will new weakest of those was in fact anywhere between Bmi and you will femoral neck BMC. The correlations ranging from many years and you will BMD and you can BMC symptoms was indeed negative (Dining table cuatro).

This-modified proportion off BMD and you can BMC adaptation said by Body mass index and you can weight are found into the Table 5. Lbs had a tendency to tell you better variations in BMD and you will BMC shipment whatsoever new examined skeletal internet compared to Bmi. This was shown by steeper hill (?) of your own respective linear regression contours. The very best difference in BMD and BMC shipment searched in the trochanter BMC accompanied by lumbar BMC to own pounds. Weight is an important predictor regarding BMD and you will BMC adaptation inside more mature Iranian people.

4. Conversation

In this study, both BMI and weight were associated with BMD, and obesity significantly decreased the risk for osteoporosis in men. These results are consistent with most previous studies, particularly in postmenopausal women, which indicated that lower BMI and weight were associated with lower BMD. Prospective studies found that the early postmenopausal women who have low BMI lose more bones compared to those with higher BMI tertiles [4, 8]. In other cross-sectional studies, however, thinness is related to both osteoporosis and increased fracture risk [10, 11]. Iqbal et al. found that low BMI is a good indicator for referral of women less than 60 years old for measurements of BMD. Similar studies also reported a consistent finding that lower BMI was associated with lower BMD [5, 6, 28]. In a study similar to ours, those with lower BMI were at higher risk of low BMD . The Studies of National Osteoporosis Foundation and others suggested that low BMI should be included in the risk assessment tools for evaluation of osteoporosis and osteoporotic fracture risk [29–31]. We found that men with BMI < 25 had 4.4 (95% CI 1.5, 12.8) times higher age-adjusted risk of osteoporosis than men with BMI ? 25. In contrast, Steinschneider et al. in a cross-sectional study reported that the correlation between BMD at the femoral neck and BMI was highly positive among postmenopausal women. A hospital-based study conducted in elderly men reported that overweight and obese men were more likely to have osteoporosis and osteopenia . The possible explanation for the discrepancies between these results might be related to populations, research designs, sampling methods, and methodological differences.

The systems wherein fatty tissue exerts positive effects on the BMD position aren’t completely clear. The fresh new putative mechanism benefit off fat getting skeletal ethics most likely resides in the newest character many adipokines in the bones renovations as a consequence of impact on both creation and you may resorption. Recently, limbs could have been noticed an enthusiastic hormonal organ affecting pounds control and you can glucose homoeostasis from procedures regarding bone-derived items such osteocalcin and you may osteopontin [23, 34–36]. The fresh new putative crosstalk between pounds as well as the bones comprises a beneficial homoeostatic opinions program in which adipokines and you may molecules released of the osteoblasts and you can osteoclasts represent the hyperlink regarding an active bones-adipose axis [34–36]. Being obese is also with the BMD by the conversion out of androgen so you’re able to estrogen , and therefore improves limbs mass in group [38, 39] and you will retains fit plasma degrees of insulin and you may regulating facts together with insulin-such as for example increases basis-step 1, leptin, and adiponectin . On the other hand, obesity will bring padding into hip if there is a fall . However, this new mechanisms wherein all these situations are present remain not sure.


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